MAPT and Brain atrophy: Alternatively, our findings may be due to our inclusion of tau as a covariate as well as Aβ42, or use of BSI rather than Freesurfer methods; hippocampal measures have been previously been found to be highly variable between techniques, likely due to differing definitions of the region (Cash et al., 2015).Our study extends these findings by showing that greater longitudinal hippocampal atrophy is seen in control subjects with a higher burden of WMHs, after adjusting for concurrent brain atrophy and CSF biomarkers.