MAPT and Atrophy: However, in models adjusting for CSF Aβ42, CSF tau, VRFs and age, WMH volume was found to be associated with hippocampal atrophy after adjusting for concurrent whole‐brain atrophy; with a doubling of WMH volume associated with an increase in atrophy rate of 0.005 ml/year (0.001–0.009) see Supporting Information Table 3.