It was shown that mutant POLB (Y265C) repairs DNA significantly more slowly than do wild-type (WT) Pol β, and mutant POLB mice develop dermatitis, GN, cervical lymphadenopathy, and high titers of ANA, i.e., pathology resembling SLE (Senejani et al. 2014). This evidence concerns the gene POLB and ganglioneuroma.