A large GWAS comparing LN with SLE patients in an attempt to discover LN susceptibility genes found PDGFRA (involved in matrix synthesis, chemotaxis, and cytokine production) and Hyaluronan synthetase 2 (HAS2; also involved in extracellular matrix production) to be strongly associated (Chung et al. 2014). This evidence concerns the gene PDGFRA and lobular neoplasia.