TLR7 and systemic lupus erythematosus: Subsequently, TLR7 was identified as the causative gene in the Yaa cluster (Deane et al. 2007) and a candidate-gene association (CGA) study reported that a functional polymorphism in 3′ UTR of TLR7 was associated with SLE in Asian populations, with a stronger effect in male than female subjects (Shen et al. 2010).