IFIH1 and Aicardi-Goutieres syndrome: AGS involves recessive and dominant mutations in RNAses (RNASEH2A, RNASEH2B, RNASEH2C), a DNAse (TREX1), double-stranded RNA (dsRNA) editing (ADAR), dsRNA recognition and binding (IFIH1), and activation of the innate immune system (SAMHD1, IFIH1) (Crow et al. 2015).