Only a few studies have investigated the association between the cetuximab response and HB-EGF expression, and the data are inconsistent: HB-EGF expression was positively correlated with disease control and median progression-free survival in metastatic colorectal cancer patients treated with cetuximab or panitumumab (Yoshida et al. 2013). The gene discussed is HBEGF; the disease is metastatic colorectal cancer.