Using various biochemical assays; immunohistochemistry (IHC), tissue micro-arrays, and reverse transcriptase-polymerase chain reactions (PCR), uPAR expression can be assessed directly in tumor specimens and is particularly high in cancer cells at the very front of the invasive tumor as well as in tumor-associated stromal cells, such as fibroblasts and macrophages [10–12]. Here, PLAUR is linked to neoplasm.