PLAUR and pachyonychia congenita: In addition, pre-operative circulating total uPAR levels were found to be higher among patients with higher biopsy Gleason grade, extraprostatic extension, and lymph node positive disease after radical prostatectomy, and, indeed, PC patients with bone metastasis exhibited significantly higher uPAR levels compared with patients with localized disease or patients with lymph node metastasis [30].