JAK2 and esophageal cancer: This study also found that STAT3 binds to AURKA promoter and antagonizes p53-mediated repression of AURKA. Intriguingly, a recent study has shown that Aurora-A promotes STAT3 activity through regulating expression and phosphorylation levels of JAK2 in gastric and esophageal cancers (29), indicating the existence of negative feedback regulation of p53 function by Aurora-A–JAK2–STAT3 axis.