TP53 and cancer: In the following sections, we summarize the current knowledge of Aurora kinases–p53 protein family signaling cascades relevant to the regulation of posttranslational modifications and stability of proteins, activity and integrity of centrosomes, checkpoint pathways in normal and aberrant mitosis, as well as protein–protein interactions and transcription and translation of genes involved in the development of pluripotent embryonic stem cells (ESC) and cancer stem cells (CSC), as outlined in the schematic overview diagram in Figure 2.