It can be shown in Figure 4 that the activation of phospho-JAK2 (Figures 4A–C) was inhibited, and the expressions of PIAS3 (Figures 4A,D), SOCS1 (Figures 4A,E), and SOCS3 (Figures 4A,F) were increased in the colonic mucosa from colitis mice treated by curcumin. Here, PIAS3 is linked to colitis.