Unlike previous reports in melanoma and lymphoma cells (Marquardt and Center, 1991; Palanca-Wessels et al., 1998), in EAC cells esomeprazole did not induce the release of cytochrome C from the mitochondria, which suggests that in our model PPI-induced apoptosis might be independent from the caspase activation pathway. The gene discussed is CYCS; the disease is melanoma.