PLAT and Stroke: Finally, melatonin has been combined with other drugs, such as t-PA (Chen T. Y. et al., 2006), topiramate (Ozyener et al., 2012), nimodipine and other Ca2+ antagonists (Gelmers et al., 1988; Toklu et al., 2009), meloxicam (Gupta et al., 2002) for stroke therapy, giving promising results.