The Amyloid Precursor Protein (APP) is the source of beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's disease (AD), but APP also has been implicated in multiple aspects of neurogenesis and neuronal differentiation (Jung and Herms, 2012; Sosa et al., 2013; Nicolas and Hassan, 2014). The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.