GRIA2 and brain neoplasm: Regarding GluA2 under-editing, which was more pronounced in glioblastoma compared to neighboring non-tumor tissue (Hwang et al., 2016), and taking into account that brain tumor cells can release glutamate by transferrin-mediated iron accumulation (Chirasani et al., 2009), reduced RNA editing and increased calcium signaling through GluA2 may contribute to aggressiveness of tumor growth and expansion.