It turned out that: (i) the GluA2 Q/R site editing belongs to the stably high editing pattern with 100% editing in all patients analyzed aged from 5 years to 57 years at the time of surgery; (ii) epilepsy could not perturb this stably high pattern; and (iii) epilepsy in mice due to deficient GluA2 Q/R site editing probably was an artifact of genetic engineering (Krestel et al., 2013). The gene discussed is GRIA2; the disease is epilepsy.