Regarding GluA2 under-editing, which was more pronounced in glioblastoma compared to neighboring non-tumor tissue (Hwang et al., 2016), and taking into account that brain tumor cells can release glutamate by transferrin-mediated iron accumulation (Chirasani et al., 2009), reduced RNA editing and increased calcium signaling through GluA2 may contribute to aggressiveness of tumor growth and expansion. Here, GRIA2 is linked to neoplasm.