A similar interaction between NTSR3/sortilin and NT receptors has been already demonstrated for NTSR1 expressed in the colonic adenocarcinoma cell line HT29 in which its physical association with NTSR3/sortilin led to a decrease of both the affinity of NT for NTSR1 and the NTSR1-mediated biological response (i.e., IPs turnover) (Martin et al., 2002). The gene discussed is NTSR1; the disease is colon adenocarcinoma.