VPS35 and Parkinson disease: Taken together, all VPS studies (except VPS35) identified 4 variants in M-PD (4/2547, 0.157%, Table 1), and 3 variants in atypical PD (3/229, 1.31%), confirming the relevance of genetic analysis of the trimeric sub-complex of the retromer both in PD and atypical parkinsonism.