Recently we have observed that certain interaction exists between TNF-α and MMP-2 during the course of septic arthritis in S. aureus infected mice, hence further experiments are warranted to figure out the impact of TNF-α on MMP-2 activation via receptors for TNF-α (TNFR-I and TNFR-II) during S. aureus induced septic arthritis [56]. The gene discussed is TNF; the disease is bacterial arthritis.