CXCL8 and meningeal tuberculosis: Further functional analysis of the differentially abundant transcripts also indicated significant up-regulation of several immunological pathways, including inflammasome activation, antigen-presenting cell maturation, and interleukin 8 signaling (Figure 2B), suggesting that patients in whom TBM-IRIS would develop had differences in innate immune response before and after antitubercular therapy and ART.