Remarkably, genes regulated by activin in macrophages showed a significant positive correlation with genes that were shown to be upregulated in murine mammary TAMs in two independent studies (Ojalvo et al, 2009; Franklin et al, 2014) and also in bone marrow TAMs from mice with leukemia (Galletti et al, 2016) (Fig 4D). Here, INHBE is linked to leukemia.