MMP‐14 and its downstream effector MMP‐2 are major players in angiogenesis and tumorigenesis (Kessenbrock et al, 2010), and MMP‐13 promoted tumor angiogenesis, melanoma invasion, and metastasis (Zigrino et al, 2009; Kudo et al, 2012). This evidence concerns the gene MMP13 and melanoma.