INHBE and esophageal squamous cell carcinoma: Furthermore, expression of macrophage chemoattractant protein‐1 and macrophage infiltration are associated with angiogenic promotion and poor prognosis in esophageal SCC (Koide et al, 2004), where activin is also overexpressed (Yoshinaga et al, 2003), and with malignant transformation of keratinocytes in human skin (Takahara et al, 2009).