Inhibition of PD‐L1 strongly enhanced tumor response to high (12 Gy, 5 × 3 Gy, 20 Gy) but not low (6 Gy, 5 × 2 Gy) RT doses, and to gemcitabine‐based chemoradiotherapy in different mouse models of PDAC. The gene discussed is CD274; the disease is neoplasm.