In contrast, CLL cells are more dependent on fatty acid oxidation due to their relatively high expression and/or activity of two members of the nuclear peroxisome proliferator activated receptor (PPAR) family PPARα (Spaner et al., 2013, Masoodi et al., 2014) and PPARδ (Supplementary Fig. 7). The gene discussed is PPARD; the disease is B-cell chronic lymphocytic leukemia.