Accordingly, intracellular cholesterol may be handled differently by CLL cells than by normal cells and other leukemias but more experiments are needed to address the possibility that differential expression of molecules like SORL1 (Fig. 2D) and PPARδ (Supplementary Fig. 6) explain disease-specific patterns of cholesterol uptake, storage, and efflux (Schmidt et al., 2016, Skogsberg et al., 2003). Here, PPARD is linked to B-cell chronic lymphocytic leukemia.