STAT3 and B-cell chronic lymphocytic leukemia: While these results suggested a model whereby LDLs are degraded in lysosomes into free fatty acids, cholesterol, and vitamin E that enhance signal transduction in CLL cells by affecting lipid structures and cellular oxidative state, a number of samples did not exhibit enhanced STAT3-phosphorylation in the presence of LDLs (Fig. 1D, right panel).