PPARA and B-cell chronic lymphocytic leukemia: In contrast, CLL cells are more dependent on fatty acid oxidation due to their relatively high expression and/or activity of two members of the nuclear peroxisome proliferator activated receptor (PPAR) family PPARα (Spaner et al., 2013, Masoodi et al., 2014) and PPARδ (Supplementary Fig. 7).