Although a change in full-length:truncated HTR2C ratio as a consequence of SNORD115 loss has been predicted for PWS [13], our previous investigation of Htr2c pre-mRNA modification in PWS-IC mice at the whole brain level demonstrated an increase of RNA-editing in the absence of a significant effect on proportion of splice variants [18]. Here, HTR2C is linked to Prader-Willi syndrome.