Further investigation revealed the reduced anorectic efficacy of WAY-161503 in PWS-IC mice to be associated with a failure to induce appropriate downstream POMC signalling as administration of 3 mg/kg WAY-161503 substantially increased the number of cFOS-IR POMC neurons within the ARC of WT (Fig. 6a, c, C’), but not PWS-IC mice (Fig. 6b, d, D’). Here, POMC is linked to Prader-Willi syndrome.