The contribution of the 5-HT2CR to the central regulation of energy balance, together with the established role of Snord115 in modulating 5-HT2CR function and lack of SNORD115 expression in nearly all cases of PWS raises the possibility that abnormalities in 5-HT2CR-mediated feeding circuitries in brain may contribute to the overeating seen in PWS subjects. The gene discussed is SNORD115; the disease is Prader-Willi syndrome.