Increases in leukostasis have been associated with insulin resistance [34], and our previous study showed that miR-15b/16 played a role in the inhibition of insulin resistance via reduced TNFa and SOCS3 signaling and increased IGFBP-3 levels, resulting in REC protection from hyperglycemia-induced apoptosis [9]. Here, SOCS3 is linked to Hyperglycemia.