Because PP6 is involved in the DNA damage response via its ability to dephosphorylate γH2AX and antagonize DNA-dependent protein kinase (DNA-PK) [18, 19] and unrepaired meiotic or induced DNA double-strand breaks (DSBs) could cause oocyte elimination and female infertility by triggering DNA damage response pathway [32], we wondered if loss of PP6c leads to DNA damage in our case. Here, PRKDC is linked to female infertility.