Of the novel C. elegans ciliary proteins we identified, we sought to characterise RAB-28 further for the following reasons: (1) human RAB28 is associated with a possible ciliopathy (cone-rod dystrophy [62,63]), (2) many small GTPases play essential roles in ciliogenesis and ciliary membrane trafficking pathways [10], and (3) aside from reports of RAB28 localising at the basal body [62] or the cilium [64], there is a complete absence of molecular studies on this evolutionarily conserved protein that support a functional and mechanistic link to cilia. The gene discussed is RAB28; the disease is Rod-cone dystrophy.