GPT and malaria: The 14 severe AEs recorded were attributed to malaria and included fever ≥39°C (n = 5), one case of transient thrombocytopenia that met the pre-specified criterion of severe (68 x109 platelets/L), four cases of elevated alanine amino transferase (ALT) and four cases of elevated aspartate amino transferase (AST) (Fig 3 and Fig 4).