STAT4 and Behcet disease: More recently, IL-17A, IL-23R, and STAT4 polymorphisms were described in BD patients with intestinal involvement, thus suggesting that also Th17 cells may participate to the mechanisms finally leading to the organ damage.[12] In our study, we observed at mucosal level a great proportion of CD4+T cells; interestingly, these cells displayed a polarized Th1 or a Th1/Th17 phenotype.