Recently a relevant role of the transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) in promoting EMT has been proposed.67 The aberrant expression of interleukin 6 (IL-6) and its activation of STAT3 have been correlated with the development and progression of carcinomas68 and in particular with increased metastatic potential and poor outcome in epithelial tumors.69 IL-6-STAT3 signaling promotes the initiation of EMT and the acquisition of mesenchymal features in breast and head and neck cancers, by inducing the expression of Twist and Snail. Here, IL6 is linked to head and neck cancer.