These authors showed that DEDD physically interacts with the autophagic controlling complex PI3K/BCN1, leading to the autophagy-mediated lysosomal degradation of SNAIL and TWIST and consequentially to the attenuation of the EMT phenotype.30 An indirect evidence of the negative crosstalk between autophagy and EMT is represented by the observation that several anticancer compounds induce autophagy while inhibiting EMT in cancer cells.35, 36, 37. This evidence concerns the gene TWIST1 and cancer.