As well in non-tumoral and cancer epithelial cells TGFβ or other EMT inducing growth factors induce accumulation of SQSTM1/p62 that in turns stabilizes the TFGβ effector SMAD4 and TWIST1 leading to changes in the expression pattern of junctional proteins.40 In another work, Grassi et al.41 using liver specific autophagy-deficient mice (Alb-Cre;ATG7fl/fl), show that autophagy degrades SNAIL in a p62/SQSTM1-dependent manner, restraining EMT and migration in hepatocytes. The gene discussed is SNAI1; the disease is cancer.