Elevated APP and Aβ have been reported in glaucoma models,4, 51 potentially linking elevated IOP promotion of APP processing, and inhibition of APP anterograde transport from the RGCL to the optic nerve.51, 52 BMD is reported to preserve optic nerve axons and active transport throughout the visual pathway in a rodent OHT model,18 which may explain the present study's finding where α2A agonists reduced levels of APP and Aβ in the RCGL of the OHT model. The gene discussed is APP; the disease is glaucoma.