IGKV2D-29 and ocular hypertension: Effects of systemic α2A agonists BMD and Clo were examined invivo using an ocular-hypertensive (OHT) rat model.30 Comparison of the IOP profile between untreated OHT control and no-OHT groups showed OHT surgery produced a significant increase in IOP up to 3 weeks post surgery (P<0.05, Figure 2a).