A role for TNF-α/IKKα in the regulation of Notch1 signaling has also been reported in liver cancer cell lines: it has been proposed that the phosphorylation of FOXA2 (critical gene required for bile acid homeostasis), by IKKα, leads to activation of Notch1 signaling through downregulation of NUMB, thereby inducing tumorigenesis.47 The gene discussed is CHUK; the disease is liver cancer.