NOTCH1 and liver cancer: A role for TNF-α/IKKα in the regulation of Notch1 signaling has also been reported in liver cancer cell lines: it has been proposed that the phosphorylation of FOXA2 (critical gene required for bile acid homeostasis), by IKKα, leads to activation of Notch1 signaling through downregulation of NUMB, thereby inducing tumorigenesis.47