In a mouse model of pancreatic cancer, it has been found that the crosstalk between TNF-α, the basal Notch signaling and Ikk2 (the Inhibitor of κB kinase 2, a component of the NF-κB signaling) induces the suppression of the nuclear receptor Pparg, which encodes for the anti-inflammatory nuclear receptor Pparγ. This evidence concerns the gene PPARG and familial pancreatic carcinoma.