The authors also found that Notch1 deficiency leads to increased expression of β-catenin expression in the epidermis, which was reverted by the re-introduction of a dominant active form of the Notch1 receptor.39 Consistently with these findings, it has been reported a reduced expression of Notch1, Notch2 and Jagged1 in human basal cell carcinomas.40 This evidence concerns the gene NOTCH1 and basal cell carcinoma.