To further confirm the autophagy-dependent promotion of tumor growth and chemoresistant effect of ASPP2 downregulation, luciferase-expressing HCC-LM3-luc cells infected with LV-shASPP2 or LV-shNon were injected into the flank of nude mice, which were treated with or without CQ and 5-FU. This evidence concerns the gene TP53BP2 and neoplasm.