Recently, ASPP2 was found to inhibit ΔNp63 expression through its ability to bind IκBβ and enhance nuclear p65/RelA, which mediates the repression of p63 in squamous cell carcinoma cells.27 In this study, however, we showed that overexpression of ASPP2 did not increase IκBβ bound with ASPP2 in HCC cells during starvation-induced autophagy (Figure 3f), suggesting the level of IκBβ expression might be limited and not the key regulator of p65/RelA in HCC cells or under nutrient-deprived environment. This evidence concerns the gene TP53BP2 and hepatocellular carcinoma.