ASPP2 is a haploin-sufficient tumor suppressor, and aberrant expression of ASPP2 has been found in a variety of human cancers, including lung cancer, breast cancer, and leukemia.18 Our previous study also found that ASPP2 is downregulated by DNA methylation in HCC.19 Recent studies have also shown that ASPP2 inhibits RAS-induced autophagic activity to dictate the cellular response to RAS.20 However, it remains unknown whether downregulation of ASPP2 is involved in the regulation of autophagy in HCC. This evidence concerns the gene TP53BP2 and cancer.