TP53BP2 and hepatocellular carcinoma: After EBSS treatment, knockdown of ASPP2 in HepG2 that with high levels of ASPP2 expression, and HCC-LM3 that with medium level of ASPP2 expression,19 increased cytoplasmic accumulation of autophagosomes and/or autolysosomes, as determined by the transmission electron microscopy (Figure 1c).