For instance, loss of MiR-200 family or MiR-205 are association with cancer metastasis.13, 14, 15 This, at least in part, attributes to its inhibitory activity toward EMT by targeting transcriptional repressors of E-cadherin, ZEB1 and ZEB2.14, 16, 17 However, MiRNAs can target various genes and single gene can be modulated by many MiRNAs, therefore, the biological outcomes of MiRNA activation may change with cell content and stimulus, which provides potential explanations for the complicated and even controversial functions of MiRNA. This evidence concerns the gene ZEB1 and cancer.