TP53 and cancer: ASPP2 belongs to the apoptosis-stimulating proteins of p53 (ASPP) family, which directly interacts with p53 family members and selectively promotes their transcriptional activities toward pro-apoptosis genes.23, 24 Further evidences from mice model revealed that ASPP2 is a haploinsufficient tumor suppressor.25 Indeed, ASPP2 expression is deregulated in several human tumor types, and ASPP2 suppression is associated with more aggressive phenotypes and poor clinical outcomes of cancers.26, 27, 28, 29 Recently, emerging evidence has suggested that ASPP2's functions do not always rely on p53.