TP53BP2 and cancer: In addition, ASPP2 has been reported to form complex with tight junction competent par-3 and regulates cell polarity of neoepithelial cells in a p53-independent manner.30, 31, 32 Moreover, it has been recently found that ASPP2 can inhibit EMT by preventing the activation of Wnt signaling in cancers.33 These data provide important molecular explanations for the clinical significance of ASPP2 in cancer metastasis.