It is also noteworthy that hypoxia is a hallmark of solid cancer.49 Cancer cells gain the capability to adapt to hypoxia via modulating gene expression patterns by utilizing different strategies.50 Hypoxia induces upregulation of MiR-205 and subsequent inhibition of ASPP2, resulting in EMT, migration and proliferation, which is thus an adaptative and protective response to hypoxia. Here, TP53BP2 is linked to cancer.