Yun et al. reported that RAD21 is expressed in epithelial breast cancer cells but not in mesenchymal cancer cells and showed that depletion of RAD21 in epithelial cancer cells created a permissive transcriptional environment within the TGFB1 and ITGA5 loci, leading to a higher expression of these integrins [145]. This evidence concerns the gene TGFB1 and breast carcinoma.