In our study, sFlt-1 positively correlated with Ang-2 (although the correlation is of moderate strength), and as we have previously shown for Ang-2 [10], it was also significantly positively correlated with the markers of kidney function (including creatinine, urea, cystatin C, uACR, uNGAL and sNGAL) and predicted kidney failure. The gene discussed is CST3; the disease is kidney failure.