ESR1 and hypertensive disorder: To investigate the components of cardiac estrogen receptors in the coexistence of hypertension and ovariectomy, the protein levels of ERα, ERβ, p-PI3K, PI3K, p-Akt and Akt in the left ventricles were excised from the WKY, SHR-Sham and SHR-OVX groups and were measured by Western blotting.