To investigate the components of cardiac estrogen receptors in the coexistence of hypertension and ovariectomy, the protein levels of ERα, ERβ, p-PI3K, PI3K, p-Akt and Akt in the left ventricles were excised from the WKY, SHR-Sham and SHR-OVX groups and were measured by Western blotting. The gene discussed is ESR2; the disease is hypertensive disorder.