In the EPIC-InterAct study [16], where they analyzed the interaction between each of the SNPs of the GRS and BMI on T2D, despite the fact that they found that the global GRS significantly interacted with BMI, these authors did not find any significant interaction of BMI with the TCF7L2 SNP after correction for multiple comparisons. Here, TCF7L2 is linked to type 2 diabetes mellitus.