Subsequently, Western blot analysis of UBE2A in these same AD and control tissues showed a significant down-regulation in UBE2A protein to about 0.36-fold of controls in Brodmann A22 neocortex and 0.27-fold in the hippocampal CA1 region, two anatomical regions targeted by the AD process (Figure 1B). The gene discussed is UBE2A; the disease is Alzheimer disease.