Therefore, we performed this study to precisely determine the association between five potentially functional SNPs (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C and rs873601G>A) in the XPG gene and gastric cancer susceptibility with a total of 1142 patients and 1173 cancer-free controls in a Southern Chinese population. This evidence concerns the gene ERCC5 and gastric cancer.