To address the functional consequence of moderate L-selectin loss we isolated L-selectinhi CD8+ T cells (>90% purity) from spleens of non-tumor bearing controls (NTB CD8+) or L-selectin intermediate-to-low (L-selectinint/lo) CD8+ cells from AT-3-bearing mice (AT-3 CD8+) (Figure 6A). This evidence concerns the gene CD8A and neoplasm.