L-selectin downregulation also occurred on splenic T cells in other tumor models including B16 melanoma and CT26 colorectal tumor, but only in rare individual mice with abundant MDSC (Figure 1—figure supplement 4), consistent with observations that these tumors do not typically induce MDSC expansion (Youn et al., 2008; Fisher et al., 2011; Ito et al., 2015). Here, SELL is linked to colorectal neoplasm.