Several studies have shown that C/EBPβ is transcriptionally activated by inflammatory stimuli, including inflammatory cytokines such as IL-6, IL-1, and TNF-α, and the role of C/EBPβ in the inflammatory cascade during the development of obesity has been discussed42, 43, 44. This evidence concerns the gene CEBPB and obesity due to melanocortin 4 receptor deficiency.