Interestingly, five genes with concordance between CNLs and down-regulation were observed in more than 50 tumor samples, including MTAP (216 samples), PTEN (143 samples), MCPH1 (86 samples), SMAD4 (63 samples), and MINPP1 (51 samples) (Fig. 4A). This evidence concerns the gene MCPH1 and neoplasm.