Nevertheless, in human, these MAP reconstructions could only be used with a lot of caution because in some human, the true pancreatic spatial distribution of activity need not be homogeneous due to a higher glucagon-like peptide-1 (GLP-1) receptor expression in certain areas of the pancreas, e.g. in the case of an insulinoma. The gene discussed is GLP1R; the disease is pancreatic insulinoma.