NFKB1 and amyotrophic lateral sclerosis: To attenuate activation of the NF-κB signaling pathway in a transgenic mouse model of ALS, we tested an extract of W. somnifera (ASH) that had the potency to reduce in a dose-dependent fashion the activity of NF-κB P65–luciferase reporter in the microglial cultured BV2 cells (Fig. 1).