GWAS have identified 40 loci in patients with psoriasis, many of which are related to immune function, including the endoplasmic reticulum aminopeptidase 1 (ERAP1), whose product is relevant to peptides binding to the MHC class I molecules, especially HLA-C*0602 and HLA-B*2746. The gene discussed is HLA-B; the disease is psoriasis.