A chromosomal rearrangement in PCa has been identified and associated with earlier precancerous lesions; it is the TMPRSS2-ERG, fusion gene between transmembrane protease serine 2 (TMPRSS2) and v-ets avian erythroblastosis virus E26 oncogene homologue (ERG). Here, TMPRSS2 is linked to posterior cortical atrophy.