It palmitoylates many synaptic proteins, including cysteine string protein (CSP), GluA1, GluA2, PSD95, synaptosomal-associated protein 25 (SNAP25), synaptotagmin 1 (SYT1), the large conductance calcium- and voltage-activated potassium BK channel (KCNMA1) STREX isoform, and the HD disease-causing protein huntingtin (HTT) [2]. Here, DNAJC5 is linked to Huntington disease.