NLRP3 and cryopyrin-associated periodic syndrome: Namely, a variable degree (5.5–34.9%) of somatic NLRP3 mosaicism vertical transmission was detected in patients with a MWS phenotype, pointing at somatic NLRP3 mosaicism as shared genetic mechanism in the whole CAPS spectrum, not restricted to CINCA/NOMID clinical picture [23, 24].