CASP1 and infection: However, excluding a significant, but seemingly unnecessary increase in IL-17 levels at day 1 post-infection in Nlrp3-/- mice, differences in the level of KC or MCP-1 that might impact myeloid cell recruitment were not discernable between Nlrp3-/-, Asc-/-, Casp1/11-/- and Aim2-/- mice.