Unlike Nlrp3-deficient mice, Aim2-/-, Caspase-1/11-/-, Asc-/-, and IL-1R-/- mice died within 8–11 dpi after lethal Ft LVS infection (Fig 3D) or between 6 and 7 dpi after SchuS4 (S3C Fig). The gene discussed is IL1R1; the disease is infection.