Unlike Nlrp3-deficient mice, Aim2-/-, Caspase-1/11-/-, Asc-/-, and IL-1R-/- mice died within 8–11 dpi after lethal Ft LVS infection (Fig 3D) or between 6 and 7 dpi after SchuS4 (S3C Fig). This evidence concerns the gene NLRP3 and infection.