CD4 and Sjogren syndrome: Furthermore, improved control of virus replication in Cre+ mice was not accompanied by virus-induced Sjögrens Syndrome-like disease, as demonstrated by comparable salivary gland accumulation of TRAILR-expressing CD4+ T cells and serum Sjögren Syndrome Antigen (SSA)-specific IgG (S4 Fig), both of which are implicated in this disease [54].