As compared to CD4-Cre-IL-10flox/flox (Cre-) control mice, Cre+ mice mounted elevated CD4+/IFNγ+ responses in the salivary glands to multiple MCMV antigens throughout the course of infection (Fig 4A), most notably M25- and m142-specific cells at d14 pi when peak IL-10+ responses were observed in Cre- mice (Fig 1B). This evidence concerns the gene CD4 and infection.