Whether GRHL2 is involved in ER/FOXA1+ breast cancer or can function independently of FOXA1 (and ER) is not clear, but GRHL2 is located on chromosome 8 and is commonly co-amplified with c-Myc, suggesting that any role for GRHL2 in mediating recruitment of the enzyme MLL3 may be substantially altered in tumors with the commonly occurring chromosome 8 amplification. The gene discussed is KMT2C; the disease is breast cancer.