BRCA1 and neoplasm: To further evaluate the in vivo anti-tumor efficacy of MPH, a subcutaneous BR-05-0028 breast patient-derived xenograft (PDX) model was used to test the treatment regimen of MPH as a single agent (BR-05-0028 with BRCA1 mutated at exon10:c.C1630T:p.Q544X; established and kept by WuXi AppTec, Shanghai, China).