Ontology analyses revealed that homeobox genes, including HOX genes, were over-represented among the genes with a recurrently hypermethylated promoter in CIMP-positive tumors (p value < 10−40) as well as in CIMP-negative tumor types (p value < 10−8), despite the small number of analyzed genes (Figure 7C). The gene discussed is LBX1; the disease is neoplasm.