To investigate whether the contribution of the MNK kinases to eIF4E phosphorylation was essential for β-catenin activity in breast cancer cells in response to chemotherapeutic drugs treatment, we exposed breast cancer cells to chemotherapeutic drugs or MNK kinase inhibitors (eg. CGP57380 and cercosporamide [7, 13]) alone, or combination. This evidence concerns the gene EIF4E and breast cancer.