The frequent inactivation of TRIM58 via hypermethylation observed even in early-stage cases from our panel of primary LADC cases was consistent with the findings of a very recent report [11] in which Diaz-Lagares et al. identified TRIM58 as one of four genes that consistently exhibited CGI hypermethylation in non-small cell lung cancers (NSCLCs) relative to non-malignant lung tissues. The gene discussed is TRIM58; the disease is non-small cell lung carcinoma.